Phenolic Composition, Antioxidant, and α-Glucosidase Inhibitory Activities of Extracts from Polygonatum sibiricum

As a traditional Chinese medicine and functional food, Polygonatum sibiricum contains many bioactive compounds with multiple biological activities. Presently, we obtained three extracts from by different solvents comparably analyzed their total phenols, flavonoids, chemical compositions. Meanwhile, the antioxidant activity attenuation of palmitic acid (PA)-induced hepatic oxidative stress these were further investigated. The results showed that active substances in inclined to dissolve ethanol (EE), twenty identified. EE exhibited best scavenging DPPH ABTS free radicals, as well reducing power. sibiricum, especially EE, could significantly increase SOD HO-1 ameliorate PA-induced HepG2 cells through Nrf2-related pathways. Furthermore, inhibit α-glucosidase effectively reduce rapid rise blood glucose induced sucrose loading.